Nutrient e.g. Protein (Optional)CaloriesProteinFatsVitamin CNet carbsCarbsCholesterolVitamin DIronCalciumPotassiumMagnesiumSugarFiberCopperZincStarchPhosphorusSodiumVitamin AVitamin E Vitamin DVitamin B1Vitamin B2Vitamin B3Vitamin B5Vitamin B6Vitamin B12Vitamin KFolateTrans FatSaturated FatMonounsaturated FatPolyunsaturated fatTryptophanThreonineIsoleucineLeucineLysineMethioninePhenylalanineValineHistidineFructose



Oranges and grapefruits are comparable in plenty of ways. Both belong come the Rutaceae family and also Citrus genus. Here we will talk about how to make the informed choice between the two, based mainly on their distinctions in nutrition and health impact.

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Both oranges and grapefruits are hybrids of other citrus fruits. Orange is a hybrid between pomelo and mandarin, whereas grapefruit is a hybrid between pomelo and sweet oranges. Naturally, oranges have been about for a lot longer period of time, the an initial mention of them gift in Chinese literature in 314 BC (1). Grapefruits, top top the other hand, were an initial described in the year 1750 and were called the “forbidden fruit” of Barbados (2).

The surname “grapefruit” allegedly originates from the reality that grapefruits thrive in clusters on trees, favor grapes. Another theory is that grapefruits have frequently been perplexed with pomelos and since pomelos are referred to as Citrus maxima, that have the right to be analyzed as “great fruit”, it has wrongly to be worded as “grapefruit”.

Externally these fruits look fairly alike. Grapefruits have tendency to it is in larger and also weigh an ext than oranges. The pulp that the most usual grapefruits, the ruby red grapefruits, is additionally usually a darker colour, much more pink than orange.


These fruits have quite similar compositions the macronutrients, yet oranges room slightly greater in protein, carbohydrates, both sugars and fiber, and also calories, while grapefruits save a little more fats. Both fruits naturally do not contain cholesterol.

Oranges, and grapefruits save some amounts of all the vital amino acids.

One point these fruits are different in is the glycemic index. Both oranges and also grapefruits autumn under the classification of low glycemic index foods, however, the glycemic index of oranges is double than the of grapefruits.

Based on Potential Renal Acid load (PRAL) oranges room a little more alkaline.

Grapefruit is the right an option between these two fruits if you are on a low carbohydrate or a short calorie diet. Yet oranges win in a low fats diet.


Oranges all at once contain much more vitamins, gift richer in vitamin C, vitamin E, vitamin B1, B2, B3 and also B6. However, grapefruits carry out contain a much higher level of vitamin A.

Both fruits contain a comparable amount of vitamin B5 and totally lack vitamin D, vitamin K, vitamin B12 and also vitamin B9 (folic acid).


Oranges are higher in many minerals as well. They contain higher concentrations of iron, calcium and potassium. Grapefruits, on the other hand, space richer in phosphorus.

Oranges and also grapefruits are around equal in the amounts of magnesium and zinc.

Both fruits perform not save sodium.

Health Impact

Cardiovascular Health

Several epidemiological studies show a relationship between the input of flavonoid-rich foods and also the palliation of cardiovascular hazard factors and mortality. In particular, flavonoids existing in citrus fruits, such as oranges and grapefruit (95% from flavanones), stand out for your high nutraceutical values. Flavonoids can lower the danger of cardiovascular diseases, such as myocardial infarction, dyslipidemia and also coronary artery pathology. The potential explanation may have to do v intracellular pathways associated in direct cardiovascular and also cardiometabolic impacts mediated by naringenin, hesperetin and eriodictyol or their glycosylated derivatives, though the mechanisms of action overall remain unclear (3).

However one research concluded that orange and grapefruit juice, though rich in polyphenols, perform not show the capacity to inhibit platelet aggregation, as opposed to the juice of another fruit well-off in polyphenols; grape juice (4). Platelet aggregation theatre a large role in atherosclerotic disease development, raising the danger of cardiovascular associated mortality and morbidity cases.

Another compound the both fruit are naturally rich in is vitamin C. A significant association has been discovered between high vitamin C intake and protection versus cardiovascular mortality, and an inverse connection with markers of inflammation (5).

Diet supplemented with fresh red grapefruit positively influences serum lipid levels of every fractions, specifically triglycerides, in addition to supporting plasma antioxidant activity. The enhancement of new red grapefruit to generally welcomed diets can be useful for hyperlipidemic, specifically hypertriglyceridemic, patients enduring from coronary atherosclerosis. Additionally, new red grapefruit contains greater quantities that bioactive compounds and also has significantly greater antioxidant potential than blond grapefruit (6).

Orange juice intake with a high fat, high carbohydrate enjoy the meal prevented meal-induced oxidative and also inflammatory stress, consisting of the rise in endotoxin and toll-like receptor (TLR) expression. This may assist explain the mechanisms basic postprandial oxidative stress and inflammation, pathogenesis of insulin resistance, and also atherosclerosis (7) and also what function orange juice can play in it.

The intake of citrus fruits may also protect versus cerebrovascular diseases, such together ischemic stroke and intracerebral hemorrhage (8).


Oranges and also grapefruits both share as low glycemic table of contents foods. Grapefruits particularly have a short glycemic table of contents of 25. Consisting of fruit, especially high in fiber and water, in diets can additionally play a significant role for civilization with metabolic syndrome, trying to control weight gain.

One examine demonstrated a considerably greater load loss in the group consuming grapefruit, grapefruit capsule, and also grapefruit juice contrasted with groups taking placebo. There was also a significant reduction in 2-hour post-glucose insulin level in the grapefruit group compared with placebo. Half of a fresh grapefruit eaten prior to meals was linked with far-ranging weight loss. In metabolic syndrome patient the result was additionally seen v grapefruit products. Insulin resistance was boosted with new grapefruit. Although the mechanism of this load loss is unknown that would appear reasonable to include grapefruit in a weight reduction diet (9).

One study argues that grapefruit juice and also orange juice pat a good role in controlling the glucose levels of experimental animals and can be used clinically on patients through diabetes and also can reduced cholesterol level. Diabetic pets treated v orange and also grapefruit had actually a reduced blood glucose concentration when compared to the diabetic manage animals. The main compound discovered in citrus fruits responsible because that this impact is stated to be naringenin, and also vitamin C, that has been report to produce hypoglycemic and also hypocholesterolemic effects because of their solid antioxidant properties. All antioxidants may create a synergistic result which may administer strengthening to the B-cells that pancreas come release more insulin (10).

Both naringenin and also vitamin C have been studied for their antidiabetic, antihyperglycemic and antioxidant effects in streptozotocin induced diabetes mellitus in rats (11). Naringin and naringenin supplementation has proven to be efficacious because that the treatment of metabolic syndrome and also obesity in pet models. In metabolic syndrome, obesity, and related cardiovascular complications, naringin influences AMP-activated protein kinase- (AMPK-), Peroxisome proliferator-activated receptor alpha- (PPARα-), and carnitine acyltransferase I- (CPT-1) mediated fat utilization and also preserves mitochondrial function. Moreover, naringin likewise prevents the TNF-α–mediated inflammatory process and tissue damages in liver and also vasculature (12).


There are countless researches researching the associations in between citrus consumption and cancer. Many studies conclude that consumption the citrus fruits carry out protection versus cancers that the digestive and upper respiratory tract tract, demonstrating a far-ranging effect also with middle citrus consumption. Compounds responsible for these results are stated to be vitamin C and flavonoids. Both, being solid antioxidants, protect against oxidative damage, inhibit the development of carcinogens and protect DNA from damage. Additionally, flavonoids have antiproliferative and antiangiogenic qualities. The pectin protein uncovered in citrus fruits additionally expresses anticancer qualities, due to its abilities to block the carbohydrate-binding the galectin-3, the is essential for the growth and also metastasis that tumor cells, and its immunomodulatory potential (13).

An Australian study found that overall, there were 48 studies reflecting a statistically significant protective effect versus cancer of citrus foods with an additional 21 studies showing a non-significant tendency to protection. Fourty one studies confirmed absolutely no effect and also 4 verified that consumption of citrus fruits substantially increased cancer risk, with another three reflecting a similar but non-significant trend. The biggest protection for enhanced citrus consumption shows up to be because that oesophageal, oro-phayngeal/laryngeal (mouth, larynx and also pharynx) and stomach cancer. For these cancers, those studies showing a protective effect of citrus fruits confirmed risk reduce of 40-50% (14).


In many cases, if a human is allergy to one citrus fruit, they room advised to avoid all citrus fruits. The allergens found in citrus fruits are not specific to one fruit, yet to all of them. These incorporate lipid move proteins, profilin and also pectin, as well as limonene, that causes contact dermatitis..

The symptom of a citrus allergy manifest us as most food allergies do. This can selection anywhere indigenous nausea, stomach pains, diarrhea, oral allergy syndrome, that contains swelling, itching, burning or redness the the mouth area to, in rare cases, anaphylaxis. Citrus fruit can also cause contact dermatitis by emotional it, in human being who room allergic come the compound dubbed limonene (15).

Citrus allergies likewise have overcome reactivity with other typical allergens, such together pollen, apples (16) or peaches (17).

Sensitivity to citric acid is not taken into consideration to it is in a component of citrus allergy, together the acid does not cause an immune reaction in the organism (18). Yet people v citric mountain sensitivity have the right to experience adverse impacts after spend citrus fruits.

Grapefruit Juice and Medication

As healthy as grapefruit juice is, the can come to be a health and wellness hazard when linked with certain medications. Grapefruit juice, and sometimes grapefruits, can negatively communicate with medicines used because that high blood pressure, high cholesterol and also depression, together as some calcium channel blockers, statins, immunosuppressants, benzodiazepines, beta blockers and other drugs.

It is said that a compound dubbed furanocoumarin, the can also be discovered in Seville (sour) oranges, is responsible because that these effects. In particular, the furanocoumarins bergapten and also dihydroxybergamottin have been studied. The mechanism resulting in this effect is the grapefruit juice’s ability to inhibit cytochrome P-450 3A4 isoenzyme and also P-glycoprotein transporters in the intestine and liver. Inhibiting the cytochrome P-450 3A4 outcomes in slowing under the gut’s metabolism, subsequently increasing the bioavailability the orally administered drugs, by a reduction in the first-pass effect. The P-glycoprotein inhibition also leads to boosted levels of the medicine in the serum, due to efflux activity of P-glycoprotein (19). Therefore, grapefruit juice boosts the impacts of particular medications by enhancing bioavailability, which can pose a significant risk to patients acquisition the drugs. Because that these patients it is recommend to move from grapefruit juice come orange juice.

A generally used drug that grapefruit juice has actually a raising effect ~ above is referred to as Sildenafil, likewise known together Viagra. Guys who take Viagra need to be careful of their grapefruit juice usage as it have the right to lead come symptoms, such together headaches, flushing and low blood press (20).


To sum up, oranges space richer in calories, protein and also carbohydrates, both fiber and also sugar, whereas grapefruits contain an ext fats. Oranges success in the vitamin category, being also richer in vitamin C, vitamin E, vitamins B1, B2, B3 and also B6. Grapefruits, however, execute contain a much higher concentration of vitamin A. When it concerns minerals, oranges contain more iron, calcium, potassium and also copper, if grapefruits are greater in phosphorus.

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Both oranges and also grapefruits possess particular cardioprotective, antidiabetic and anticancer qualities and also can be considered as useful foods. However, grapefruits and grapefruit juice have to be consumed with caution as it deserve to interfere with certain medications.