Methadone can connect with a selection of drugs. Results of medicine interactions can range from serious results on breathing, to raised overdose risk or lessened effectiveness.

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Methadone is one opioid medication that is used during opioid decoding to prevent withdrawal, law pain, and is supplied as a maintenance therapy for opioid usage disorder.

Before taking methadone, phone call your doctor if you are taking any kind of other medications, vitamins, or supplements. Some drugs can communicate with methadone and disrupt methadone treatment.

Read an ext about taking methadone because that opioid withdrawal

Types the Drugs the Can connect With Methadone

A range of prescription and also over-the-counter substances deserve to negatively communicate with methadone. The results of this have the right to be gentle to serious in nature.

Potential impacts of drug interactions have the right to include:

reduced performance of methadonedisruption come methadone metabolismincreased threat for overdoserespiratory depressionheart problems

The potential effects of mixing methadone with particular drugs have the right to vary based on the kind of drug taken v methadone, co-occurring health and wellness conditions, and other an individual factors.

Types the drugs the can communicate with methadone include:

Central Nervous device Depressants

Methadone is a central nervous system (CNS) depressant, an interpretation it slows task in the nervous system. This can impact breathing, love rate, cognition, and blood pressure.

Mixing methadone with other CNS depressants can reason a synergistic effect, which deserve to have serious and also potentially life-threatening impacts on breathing and also the heart.

Common CNS depressants include:

alcoholbenzodiazepines: alprazolam (Xanax), diazepam (Valium), lorazepam (Ativan), chlordiazepoxide (Librium), clonazepam (Klonopin), temazepam (Restoril)barbiturates: phenobarbital (Luminal), secobarbital (Seconal), pentobarbitalopioids: buprenorphine (Subutex, Suboxone), oxycodone (OxyContin), morphine, codeine, hydro-codon (Vicodin), meperidine, fentanyl, heroinother sedative-hypnotics: zolpidem (Ambien), zaleplon (Sonata), eszopiclone (Lunesta), suvorexant (Belsomra)other cough and pain medicine: dextromethorphan (Robitussin)

If you’re taking a CNS depressant, speak to her doctor around the potential dangers of continuing to use this medicine while acquisition methadone. Alternative treatments may be recommended.

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Opioid Antagonists

Opioid antagonists room drugs that deserve to block the impacts of opioids (including methadone) in the brain and nervous system.

Opioid antagonists the can interact with methadone include:

naloxonenaltrexone (Vivitrol)Suboxone (a combined agonist-antagonist)nalmefene

Taking an opioid antagonist if receiving methadone maintenance therapy can cause the methadone to it is in ineffective, or may potentially create acute withdrawal symptoms.

Anticonvulsant Medications

Some drugs supplied to regulate seizures or convulsions as a an outcome of a medical problem can interact with methadone.

Anticonvulsants the can connect with methadone include:

carbamazepine (Tegretol)phenytoinpregabalin (Lyrica)gabapentin (Horizant, Neurontin)primidone

Antibiotics and Antiretroviral Agents

Some antibiotics and antiretroviral agents (e.g. HIV/AIDs medications) can connect with methadone.

Mixing the two might reduce the efficiency of methadone, i m sorry can result in opioid withdrawal and also other effects.

Antibiotics and also HIV drugs that can interact with methadone include:


This is not a complete list. If you’re taking medication for HIV or an additional viral infection, tell her doctor before you start taking methadone.


Antifungals are medications that might be provided to treat problems such as athlete’s foot, ringworm, and also other infections that influence the skin, hair, and nails.

Antifungals the can interact with methadone include:

fluconazole (Diflucan)ketoconazoleitraconazole (Onmel, Sporanox)voriconazole (Vfend)

These drugs deserve to inhibit the management of methadone, resulting in greater concentrations that the medicine in a person’s system, which deserve to lead come toxicity.

Antidepressant Medications

Some drugs used for the treatment of depression deserve to inhibit the line of methadone, causing greater levels the the drug in a who system.

Antidepressants that can connect with methadone:

monoamine oxidase inhibitors: e.g. Marplan, Nardil, ParnateSSRIs: fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa)SNRIs: trazodone, duloxetine (Cymbalta), venlafaxine (Effexor)tricyclic antidepressants: amitriptyline (Elavil), desipramine (Norpramin), doxepin (Silenor), amoxapine, nortriptyline (Pamelor)

This is one incomplete list of antidepressants the can interact with methadone. If you space taking medication for depression, talk to your doctor before starting methadone because that OUD.

Read much more about the an unfavorable interactions the methadone and antidepressants

Arrhythmogenic Agents

Arrhythmogenic agents space drugs that can influence the heart or cause electrolyte imbalances. Merged with methadone, this has the potential to cause heart problems.

Arrhthymogenic agents might include:

antipsychotics/neuroleptics: haloperidol (Haldol), quetiapine (Seroquel), risperidone (Risperdal), olanzapine (Zyprexa), aripiprazole (Abilify), clozapineheart medications: moricizine, quinidine, dofetilide, amiodarone (Nexterone), disopyramide (Norpace), flecainidediuretics: caffeine, torsemide (Demadex), blood press medicationslaxatives: Miralax, Dulcolax, senna, Colace

Antihistamines/Allergy Medications

Antihistamines are drugs the are commonly marketed because that allergy relief, insomnia, and also may be prescribed for anxiety. These can connect with methadone.

Antihistamines the can interact with methadone include:

diphenhydramine (Benadryl, over-the-counter sleep aids)hydroxyzinecetirizine (Zyrtec)fexofenadine (Allegra)loratadine (Claritin)clemastine (Tavist)cyclizinepromethazine

Antihistamines deserve to be purchase over-the-counter (e.g. Allegra) or it is in prescribed because that a specific medical condition, such as chronic allergies.

Migraine Medications

Some prescription and also over-the-counter medicines used come treat migraine headaches can communicate with methadone.

Migraine headache medicines that can connect with methadone include:

almotriptan (Axert)naratriptan (Amerge)sumatriptan (Alsuma)frovatriptan (Frova)eletriptan (Relpax)rizatriptan (Maxalt)zolmitriptan (Zomig)


Anticholinergics are drugs that can be offered to treat a selection of conditions, consisting of overactive bladder, COPD, cradle disorders, and symptoms of Parkinson’s disease.

Anticholinergics that can communicate with methadone include:

atropine (Atropen)Enablex (darifenacin)Ditropan (oxybutynin)aclidiniumbenztropine mesylatetrihexyphenidylantihistaminestricyclic antidepressantsantipsychotic medications

These drugs can communicate with methadone. Acquisition anticholinergics while acquisition methadone may cause severe constipation and difficulty urinating (severe urinary retention).

Illicit Drugs

Taking illicit drugs while using methadone have the right to have harmful and also potentially life-threatening impacts on breathing, heart function, and also liver and also kidney function.

Illicit drugs the can connect with methadone include:

cocaineheroinillicitly-manufactured fentanyl

Mixing any illicit drugs through methadone can potentially lead to diminished effectiveness of methadone treatment. Preventing the usage of illicit drugs while acquisition methadone is recommended.

What come Do prior to Taking Methadone If girlfriend Take other Medications

Before starting methadone, tell your doctor around any supplements, prescription medications, or other substances you room taking. This contains the usage of alcohol and over-the-counter drugs.

Learn more About Methadone Treatment choices Today

If you’re concerned about other drugs communicating with methadone, an seeks treatment expert can help you construct a treatment setup that is suitable to meet your needs.

Some drugs that communicate with methadone can still be taken through precautionary actions in place to stop harmful health and wellness outcomes.

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For much more information around methadone treatment options, speak to our helpline to speak to among our trained employee members today.